林自力，副教授，2016年获韩国国立忠北大学博士学位；2016年-2019年在清华大学从事博士后研究，2019年在清华大学被聘为副研究员；2021年2月至今在澳门十大娱乐网站官网工作。已在《Nature》、《Science》、《NAT CELL BIOL》、《Molecular Cell》等期刊上发表论文二十余篇。近五年以共同第一作者身份在《Nature》（影响因子69.5）和《NAT CELL BIOL》（影响因子29.5）上发表论文各一篇，授权国际专利1项，论文他引500余次。主要承担本科生《科学研究方法》、《动物胚胎工程》，研究生的《表观遗传学进展》、《动物基因组学》、《动物繁殖理论与生物技术》等课程的授课。

联系方式：talzl@163.com

研究方向：动物生殖生理与繁殖研究。

科研项目：

1、（项目号：5076016182/023）澳门十大娱乐网站官网青年教师科研创新能力提升计划“小鼠休眠胚胎体系的建立与优化”（2022-2023）主持。

2、（项目号：KM202210020003）北京市教委一般项目“小鼠胚胎休眠过程中转录因子的分布机制和功能研究”（2022-2024）主持。

3、（项目号：Z181100001318006）北京市科学技术委员会-生命科学前沿创新培育“早期胚胎基因组启动与异常发育相关研究”（2018-2021）参加。

4、（项目号：2023YJS010） 2023年澳门十大娱乐网站官网学位与研究生教育改革与发展项目，研究生《分子生物学进展》创新模式探究（2023）主持。

代表性论文：

1、Wu JY#, Xu JW#, Liu BF#, Yao GD#, Wang PZ#, Lin ZL#, Huang B, Wang XP, Li T, Shi SL, Zhang N, Duan FY, Ming J, Zhang XY, Niu WB, Song WY, Jin HX, Guo YH, Dai SJ, Hu LL, Fang LL, Wang QJ, Li YY, Li W, Na J, Xie W, Sun YP. Chromatin Analysis in Human Early Development Reveals Epigenetic Transition During ZGA. Nature. 2018; 557: 256–260. (#Co-first author). IF=69.5.

2、Xiong ZQ#, Xu K#, Lin ZL#, Kong F#, Wang QJ#, Quan YJ#, Sha QQ, Li FJ, Li L, Xie W. Ultrasensitive Ribo-seq reveals translational landscapes during oocyte-to-embryo transition and early development, NAT CELL BIOL. 2022; 24, 968–980. (#Co-first author). IF=29.

3、Lin ZL, Xu YN, Namgoong S, Kim NH. JMY Functions as Actin Nucleation-Promoting Factor and Mediator for p53-Mediated DNA Damage in Porcine Oocytes. PLOS ONE. 2014; 9(10): e109385.

4、Lin ZL, Ni HM, Liu YH, Sheng XH, Cui XS, Kim NH, Guo Y. Effect of anti-PMSG on Distribution of Estrogen Receptor Alpha and Progesterone Receptor in Mouse Ovary, Oviduct and Uterus. Zygote. 2015; 23(5):695-703.

5、Lin ZL, Li YH, Xu YN, Wang QL, Namgoong S, Cui XS, Kim NH. Effects of Growth Differentiation Factor 9 and Bone Morphogenetic Protein 15 on the in Vitro Maturation of Porcine oocytes. Reprod Domest Anim. 2014; 49(2):219-27.

6、Lin ZL, Kim NH. Role of Ataxia-Telangiectasia Mutated (ATM) in Porcine Oocyte in vitro Maturation. Cell Biol Int. 2015; 17; 39(6):710-20.

7、Lin ZL, Cui XS, Namgoong S, Kim NH. Junction-mediating and regulatory protein (JMY) is Essential for Early Porcine Embryonic Development. J Reprod Dev. 2015; 61(5):361-7.

8、Lin ZL, Li YH, Jin YX, Kim NH. A Maternal Transcription Factor, Junction Mediating and Regulatory Protein is Required for Preimplantation Development in the Mouse. Dev Reprod. 2019 23(3), 285-295.

9、Ji SY, Chen FL, Stein P, Wang JC, Zhou ZM, Wang LJ, Zhao Q, Lin ZL, Liu BF, Schultz RM, Xie W. OBOX regulates murine zygotic genome activation and early development. Nature. 20230717.

10、Lu XK #, Zhang Y#, Wang LJ#, Wang LY#, Wang H, Xu Q, Xiang Y, Chen C, Kong F, Xia W, Lin ZL, Ma S, Liu L, Wang X, Ni H, Li W, Guo Y, Xie W. Evolutionary epigenomic analyses in mammalian early embryos reveal species-specific innovations and conserved principles of imprinting. Science Advances. 2021 Nov 26;7(48): eabi6178.

11、Zhang HM, Ji SY, Zhang K, Chen, Y., Ming J., Kong F., Wang L., Wang S., Zou ZN., Xiong ZQ., Xu K., Lin ZL, Huang B., Liu L., Fa, Q., Jin S., Deng HT, & Xie W. (2023). Stable maternal proteins underlie distinct transcriptome, translatome, and proteome reprogramming during mouse oocyte-to-embryo transition. Genome Biol, 24(1), 166.

12、Zhang K #, Wu DY #, Zheng H #, Wang Y #, Sun QR, Liu X, Wang LY, Xiong WJ, Wang QJ, Rhodes J, Xu K, Li LJ, Lin ZL, Yu G, Xia WK, Huang B, Du ZH, Yao Y, Nasmyth KA, Klose RJ, Miao YL Xie W. Analysis of Genome Architecture during SCNT Reveals a Role of Cohesin in Impeding Minor ZGA. Mol Cell. 2020. 79:234-250.

13、Liu BF #, Xu QH #, Wang QJ #, Feng S, Lai FN, Wang PZ, Zheng FY, Xiang YL, Wu JY, Nie JW, Qiu C, Xia WK, Li LJ, Yu G, Lin ZL, Xu K, Xiong ZQ, Kong F, Liu L, Huang CY, Yu Y, Na J, Xie W. The landscape of RNA Pol II binding reveals a stepwise transition during ZGA. Nature. 2020; 587, 139-144.

14、Jang WI, Lin ZL, Lee SH, Namgoong S, Kim NH. A Specific Inhibitor of CDK1, RO-3306, Reversibly Arrests Meiosis During in vitro Maturation of Porcine Oocytes. Anim Reprod Sci. 2014; 144 (3-4): 102-8.

15、Wang HY, Lin ZL, Yu XF, Cui XS, Kim NH. Computational Prediction of Alzheimer’s and Parkinson’s Disease microRNAs in Domestic Animals. Asian Australas. J. Anim. Sci. Search. 2016; 29(6):782-92.

16、Luo YB#, Zhang L#, Lin ZL, Ma JY, Jia J, Namgoong S, Sun QY. Distinct Subcellular Localization and Potential Role of LINE1-ORF1P in Meiotic Oocytes. Histochem Cell Biol. 2016;145(1):93-104.

17、Du ZH#, Zheng H#, Kawamura KK#, Zhang K#, Gassler J, Powell S, Xu QH, Lin ZL, Xu K, Zhou Q, Ozonv EA, Véron N, Huang B, Li LJ, Yu G, Liu L, Wang PZ, Chang L, Wang QJ, He AB, Sun YJ, Na J, Sun QY, Sasaki H, Tachibana K, Peters A, Xie W. (2020) Polycomb Group Proteins Regulate Chromatin Architecture in Mouse Oocytes and Early Embryos. Molecular Cell 77(1-15).

18、Xia WK#, Xu JW#, Yu G#, Yao GD#, Xu K,† Ma XS,† Zhang N,† Liu BF, Li T, Lin ZL, Chen X, Li LJ, Wang QJ, Shi DY,Shi SL, Zhang YL, Song WY, Jin HX, Hu LL, Xie W, Sun YP. (2019) Resetting Histone Modifications During Human Parental-to-zygotic Transition. Science. 2019; 26;365(6451):353-360.

19、Wang HY, Luo YB, Lin ZL, Cui XS, Kim NH. Effect of ATM and HDAC Inhibition on Etoposide-induced DNA Damage in Porcine Early Preimplantation Embryos. PLOS ONE. 2015 Nov 10;10(11): e0142561.

20、Wang HY, Guo J, Lin ZL, Namgoong S, Oh JS, Kim NH. Filamin A is required for spindle migration and asymmetric division in mouse oocytes. FASEB J. 2017 Aug;31(8):3677-3688.

21、Lee SK, Zhao MH, Kwon JW, Li YH, Lin ZL, Jin YX, Kim NH, Cui XS. The Association of Mitochondrial Potential and Copy Number with Pig Oocyte Maturation and Developmental Potential. J Reprod Dev. 2014; 60(2): 128-35.

22、Wang H, Luo Y, Zhao MH, Lin ZL, Kwon J, Cui XS, Kim NH. DNA Double-strand Breaks Disrupted the Spindle Assembly in Porcine Oocytes. Mol Reprod Dev. 2016; 83(2):132-43.

23、Lin ZL, Kwon JW, Kim NH. Effect of Recombinant Growth Differentiation Factor 9 (GDF 9) and Bone Morphogenetic Protein 15 (BMP 15) on MAPK and MPF Signals in Porcine Oocytes in vitro maturation. Bulletin of Animal Biotechnology. 2013 (5):44-51.

24、Lee SK, Zhao MH, Li YH, Lin ZL, Jin YX, Kim NH, Cui XS. Mitochondrial Membrane Potential is Critical to Porcine Oocyte Maturation in Vitro. Reproductive & Developmental Biology. 2013, 37(2):99-116.

25、林自力,高雅,邓桂馨,梁鸿斌,张鸿波,刘云海,倪和民,郭勇,王志刚. PMSG 和 FSH 同期发情处理对小鼠子宫，卵巢和输卵管中雌激素 α 受体分布的影响. 中国实验动物学报［J］. 2010，18(3) :204-207.

26、林自力, 倪和民, 郭勇, 梁鸿斌, 尹艳云, 邓桂馨, 刘云海. PMSG 和 FSH 同期发情处理对小鼠卵巢，输卵管和子宫中受体分布的影响. 中国比较医学杂志［J］. 2011,21(5): 11-14.

27、林自力, 何艳芳, 卢婷婷, 康 蕊, 秦秀蕊, 张 鑫, 倪和民. 稀释液中分别添加不同浓度咖啡因或谷胱甘肽对犬精液冷冻效果的影响. 中国农学通报［J］. 2010,26(8):21-24.

28、高雅， 林自力， 张鸿波， 梁鸿斌， 刘云海， 郭勇， 倪和民. 自然发情与诱导发情小鼠子宫内膜中雌激素受体 α 表达的比较. 中国实验动物学报［J］. 2010,18(2):168-172 20.

国际专利：

专利名称：简单易用的PAT实验分析方法（韩国第10-2014-0049404 号）